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Familial Atrioventricular Nodal Reentry Tachycardia
Author(s) -
Hayes John J.,
Sharma Param P.,
Smith Peter N.,
Vidaillet Humberto J.
Publication year - 2004
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2004.00388.x
Subject(s) - medicine , reentry , nodal , cardiology , tachycardia , atrioventricular node , supraventricular tachycardia , radiofrequency ablation , ablation , nodal signaling , biochemistry , chemistry , gastrulation , embryonic stem cell , gene
Dual atrioventricular nodal pathways, the substrate responsible for atrioventricular node reentry tachycardia (AVNRT), are thought to be randomly occurring congenital anomalies. This article describes 14 patients in six families, each with two or three first‐degree relatives with paroxysmal supraventricular tachycardia. Electrophysiological evidence of dual atrioventricular nodal pathways was established in all 13 patients studied, AVNRT was induced in 12 (92%), and radiofrequency ablation of the slow pathway was curative in all cases. The data suggest a hereditary contribution to the development of atrioventricular nodal pathways and AVNRT. The pattern of inheritance appears to be autosomal dominant. (PACE 2004; 27:73–76)