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Assessment of Autonomic Nervous System Functions in Patients with Vitamin B 12 Deficiency by Power Spectral Analysis of Heart Rate Variability
Author(s) -
AYTEMIR KUDRET,
AKSÖYEK SERDAR,
BÜYÜKASIK YAHYA,
HAZNEDAROĞCLU IBRAHIM,
ALAR ENVER,
ÖZER NECLA,
ÖVÜNÇ KENAN,
ÖZMEN FERHAN,
OTO ALI
Publication year - 2000
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2000.tb00883.x
Subject(s) - medicine , heart rate variability , autonomic nervous system , vitamin b , endocrinology , cardiology , vitamin , heart rate , physiology , gastroenterology , blood pressure
The purpose of this study was to test the autonomic nervous system function of patients with vitamin B 12 deficiency (megaloblastic anemia) by measuring heart rate variability (HRV). The study population consisted of 17 vitamin B 12 deficient patients and 15 age‐ and sex‐matched normal volunteers. HRV was measured by power spectral analysis from which power of the low frequency (LF) peak (0.04–0.15 Hz), normalized units of the LF peak (LFNU), power of the high frequency (HF) peak (0.15–0.4 Hz), normalized units of the HF (HFNU), and ratio of power of LF to power of HF (LF:HF) were calculated. Vitamin B 12 deficient patients had lower LF, LFNU, HF, HFNU, and LF:HF ratio than normal volunteers (P < 0.05). Decreases in sympathetic indices (LF and LFNU) were greater than those measured in parasympathetic indices (HF and HFNU). All HRV parameters correlated positively with the level of vitamin B 12 (P < 0.001) and negatively with the duration of disease (P < 0.001). After vitamin B 12 replacement the HEV parameters of patients and controls became comparable (P > 0.05). Our data suggest that autonomic sympathetic and parasympathetic nervous activities are decreased in patients with vitamin B 12 deficiency, an abnormality that can be corrected by vitamin B 12 replacement therapy.