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Complete Atrioventricular Block after Arsenic Trioxide Treatment in an Acute Promyelocytic Leukemic Patient
Author(s) -
HUANG CHIENHUA,
CHEN WENJONE,
WU CHAUCHUNG,
CHEN YAOCHANG,
LEE YUANTEH
Publication year - 1999
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1999.tb06826.x
Subject(s) - arsenic trioxide , medicine , acute promyelocytic leukemia , discontinuation , heart block , atrioventricular block , arsenic , block (permutation group theory) , electrocardiography , retinoic acid , biochemistry , materials science , chemistry , geometry , mathematics , metallurgy , gene
A V block after arsenic trioxide (As 2 O 3 ) treatment for refractory acute promyelocytic leukemia is very rare. In this patient, the block was at A‐H level and manifested with complete AV block and Wenckebach second‐degree type 3:2 block. The junctional recovery time during complete AV block did not significantly prolong after administration of more arsenic trioxide. The effect of heart block of arsenic trioxide seemed reversible after the discontinuation of arsenic trioxide and was not correlated to the leukemic status as observed in this patient.