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Nicorandil, a Potassium Channel Opener, Abolished Torsades de Pointes in a Patient with Complete Atrioventricular Block
Author(s) -
WATANABE OTSU,
OKUMURA TARO,
TAKEDA HIROSHI,
NAKAMURA WAKO,
SEGAWA KAZUHIKO,
ITO HIROYUKI,
YOSHIMOTO NOBUO
Publication year - 1999
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1999.tb00516.x
Subject(s) - nicorandil , medicine , torsades de pointes , potassium channel opener , lidocaine , bradycardia , qt interval , cardiology , anesthesia , heart block , atrioventricular block , ventricular fibrillation , electrocardiography , potassium channel , heart rate , blood pressure
TdP is a serious complication of AV block. We report a case of complete AV block with QT prolongation who had bouts of TdP resistant to lidocaine and isoproterenol. Temporary pacing could not be performed, because insertion of a pacing lead triggered TdP that deteriorated into ventricular fibrillation. Nicorandil, a potassium channel opener, shortened the QT interval and abolished TdP. This may suggest that potassium channel opening drugs are clinically effective against TdP associated with bradycardia‐dependent QT prolongation.