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Assessment of the Coupling Between RT apex and RR Interval as an Index of Temporal Dispersion of Ventricular Repolarization
Author(s) -
LOMBARDI FEDERICO,
COLOMBO ANDREA,
PORTA ALBERTO,
BASELLI GIUSEPPE,
CERUTTI SERGIO,
FIORENTINI CESARE
Publication year - 1998
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1998.tb01189.x
Subject(s) - medicine , cardiology , apex (geometry) , dispersion (optics) , repolarization , index (typography) , interval (graph theory) , coupling (piping) , ventricular repolarization , anatomy , electrophysiology , optics , combinatorics , mathematics , physics , mechanical engineering , world wide web , computer science , engineering
To evaluate the dynamic characteristics of the relationlship between the RT and RR intervals we analyzed the RR/RT apex variability interaction with a dynamic parametric model whose parameters can be directly estimated from the beat‐to‐beat series RR and RT opex intervals. The model is designed to separate the fraction of RT apex variability driven by RR changes from that independent of RR variations and to quantify the gain and phase of the relationship between RR and RT apex intervals. The percentage of RT apex variability driven by RR variability was significantly greater in young normal subjects in comparison with postmyocardial infarction patients as well as with agematched control subjects. This new approach based on the quantification of the RT apex variability dependent and independent of beat‐to‐beat RR interval changes could be used to quantify the degree of uncoupling between the two signals thus providing a new and noninvasive index of temporal dispersion of ventricular repolarization.