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An Approach to the Detection of Autonomic Neuropathy hy Use of Signal‐Averaged Electrocardiography
Author(s) -
YAMADA TAKAHISA,
FUKUNAMI MASATAKE,
OHMORI MASAHARU,
KUMAGAI KAZUAKI,
ABE YASUSHI,
NISHIKAWA NAGAHIRO,
HORI MASATSUGU,
KAMADA TAKENOBU,
HOKI NORITAKE
Publication year - 1997
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1997.tb06169.x
Subject(s) - medicine , qrs complex , signal averaged electrocardiogram , cardiology , electrocardiography , attenuation , qt interval , beat (acoustics) , acoustics , physics , optics
The beat‐to‐beat variation of PR interval, which is thought to be a reflection of autonomic nervous system, is difficult to measure with accuracy because the variation is too subtle. However, R wave amplitude in the P wave triggered SAECG is easily attenuated in comparison to that in the R wave triggered SAECG, which might he due to PR interval fluctuation. To determine whether autonomic neuropathy could be detected by use of SAECG, two types of SAECGs triggered by P and R waves were recorded in 23 diabetics with autonomic neuropathy and 41 age matched controls. The peak voltage of filtered QRS complex was measured in the R wave and P wave triggered SAECGs. Percent attenuation of the filtered QRS voltage was calculated by dividing the difference between the voltages in the R wave and P wave triggered SAECGs by the voltage in R wave triggered SAECG. The percent attenuation of filtered QRS voltage was significantly smaller in diabetics with autonomic neuropathy than controls (4.6%± 4.9% vs 16.3%± 15.0%; P < 0.001). These results suggest that the degree of attenuation of filtered QRS voltage in the P wave triggered SAECG would be useful for the detection of autonomic neuropathy.