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Determinants of Nonthoracotomy Biphasic Defihrillation
Author(s) -
HORTON RODNEY P.,
CANBY ROBERT C.,
ROMÁN CARLOS A.,
HULL MICHAEL L.,
KAYE SUSAN A.,
JESSEN MICHAEL E.,
PAGE RICHARD L.
Publication year - 1997
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1997.tb04812.x
Subject(s) - medicine , univariate analysis , ejection fraction , univariate , cardiology , body surface area , heart failure , multivariate analysis , multivariate statistics , statistics , mathematics
The clinical variables affecting DFT for ICD systems are not completely determined, especially with regard to biphasic shocking devices. To distinguish which factors correlate with DFT, we examined data from patients who were enrolled in the Ventak P2/Endotak protocol. A total of 284 patients were enrolled in the study. Two patients had a DFT > 25 J and did not receive the device; 154 did not undergo stepdown to failure DFT testing. The remaining 128 patients had formal DFT testing and were suitable for analysis. Variables available for analysis included age, body surface area (BSA), LVEF, gender, lead configuration, primary arrhythmia, primary cardiac disease, and use of cardioactive medication. Data were evaluated using regression analysis, fitting DFT (range, 1–25 J, mean 11 ± 5 J) as a function of each variable. As a univariate predictor, BSA was found to be significant in predicting DFT, but accounted for only 9% of the total variation on the DFT (P < 0.01, r = 0.3). This study suggests that DFT using a biphasic shocking waveform is modestly influenced by the BSA of the patient. Other specific factors, including LVEF, do not predict DFT.