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Comparison of Single‐Biphasic Versus Sequential‐Biphasic Shocks on Defibrillation Threshold in Pigs
Author(s) -
CSANADI ZOLTAN,
JONES DOUGLAS L.,
WOOD G. KIM,
KLEIN GEORGE J.
Publication year - 1997
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1997.tb03528.x
Subject(s) - defibrillation , medicine , ventricle , shock (circulatory) , capacitor , cardiology , electrode , defibrillation threshold , pulse (music) , anesthesia , biomedical engineering , voltage , electrical engineering , physics , quantum mechanics , engineering
Current generation implantable cacdioverter defibrillators use monophasic, biphasic, or sequential pulse shocks, most of which truncate after a given time, dumping the remaining charge on the capacitor through an internal resistor. We hypothesized that having an additional current pathway, and delivering the majority of the remaining charge on a single capacitor to the two pathways using additional shock phases, would improve defibrillotion efficacy. This hypothesis was tested by comparing DFTs using a simulated single capacitor, single‐biphasic shock (two 5‐ms pulses separated by 0.2 ms), delivered to coupled pairs of electrodes, to those using a sequential‐biphasic shock (four 5‐ms pulses separated by 0.2 ms) delivered to separate opposing electrodes, delivered from the same electrodes for both woveforms. In eight open‐chest anesthetized pigs, four mesh electrodes (Medtronic TX‐7. 6.5 cm 2 ), were sutured on the epicardium of the anterior and posterior surfaces of each ventricle. Shocks were delivered from a 200‐μF capacitor bank. Triplicate DFTs were obtained using each waveform in a randomized crossover design. Initial leading edge voltage (mean ± SEM: 420 ± 33 V vs 497 ± 34 V; P < 0.05). initial peak current (4.8 ± 0.4 Avs 13 ± 1.1 A: P < 0.001). and delivered energy (16.9 ± 2.6 J vs 30.4 ± 5.3 f; P < 0.05) at the DFT were all significantly lower using sequential‐biphasic shocks than those using single‐biphasic shocks, respectivelv. We conclude that for direct heart defibrillation, it is worthwhile to combine sequential capability to biphasic shocks and deliver the remaining charge on the capacitor to the two different pathways.