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Torsades de Pointes from Terfenadine and Sotalol Given in Combination
Author(s) -
FEROZE HAMID,
SURI RANJIT,
SILVERMAN DAVID I.
Publication year - 1996
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1996.tb03169.x
Subject(s) - medicine , terfenadine , sotalol , torsades de pointes , qt interval , cardiology , anesthesia , atrial fibrillation
A patient receiving sotalol developed recurrent torsades de pointes following the addition of terfenadine (Seldane) to her medical regimen. A 71‐year‐old woman with a history of atrial fibrillation successfully suppressed with sotalol, 80 mg bid, was started on terfenadine, 60 mg bid. Eight days later, she developed repeated self‐terminating episodes of torsades de pointes. Sotalol and terfenadine were discontinued, and no further arrhythmia was observed after 72 hours of temporary pacing was discontinued.