Premium
A Pilot Study: Defibrillation Thresholds in Dogs are Similar with Isoflurane, Halothane, and Pentobarbital
Author(s) -
JARVIS ALISON S.,
LAHTINEN STUART P.
Publication year - 1994
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1994.tb01389.x
Subject(s) - pentobarbital , halothane , medicine , isoflurane , defibrillation threshold , defibrillation , anesthetic , anesthesia , crossover study , cardiology , alternative medicine , pathology , placebo
The objective of this pilot study was to determine if three common anesthetic drugs have differing effects on the measurement of defibrillation thresholds (DFT) in dogs. The drugs compared were pentobarbital, isoflurane, and halothane. We used six dogs, which were surgically instrumented, in a chronic study design. Each dog had two internal defibrillation patches placed on its heart, which were used to deliver the defibrillation energy. DFT was determined while each dog was anesthetized under each of the listed drugs in a crossover design. This pilot study suggests that differences in DFT due to the anesthetic drugs is not significant in studies with low numbers of animals (halothane 14.5 ± 1.0, isoflurane 14.2 ± 1.0, pentobarbital 12.8 ± 1.0;P = NS; mean ± SE). Tbe variation in DFT between individual animals is much larger than the difference in DFT due to the drugs.