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Histologic Findings of the Heart and the Conduction System in the First Patient Who Underwent Catheter Ablation
Author(s) -
BHARATI SAROJA,
SCHEINMAN MELVIN,
LEV MAURICE
Publication year - 1992
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1992.tb03140.x
Subject(s) - medicine , cardiology , fibrosis , atrial fibrillation , electrical conduction system of the heart , catheter ablation , atrioventricular node , heart failure , ablation , pathological , muscle hypertrophy , bundle branches , bundle of his , catheter , surgery , electrocardiography , tachycardia
This is a detailed pathological examination of the heart including the conduction system (CS) from a 64‐year‐old male who had catheter ablation of the atrioventricular (AV) junction for intractable atrial fibrillation. This is the world's first human who had this procedure, and who survived 3 years and 8 months, and later died of congestive heart failure. Pathologically, the heart was hypertrophied and enlarged. Historically, there were chronic inflammatory cells, marked fatty metamorphosis with fibrosis of the atria, the approaches to the AV node, and the AV node, with almost isolation of the node from the atria, and considerable fibrosis of the bundle and bundle branches. In addition, there was fibrosis of the summit of the ventricular septum with chronic inflammatory cells. These represent the sequelae of the ablation procedures. It is not known how much of the pathological findings contributed to the cardiac hypertrophy and impairment of cardiac function,