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Effect of Vagal Nerve Electrostimulation on the Power Spectrum of Heart Rate Variability in Man
Author(s) -
KAMATH M.V.,
UPTON A.R.M.,
TALALLA A.,
FALLEN E.L.
Publication year - 1992
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1992.tb03067.x
Subject(s) - medicine , evening , heart rate , heart rate variability , morning , anesthesia , vagal tone , nerve stimulator , vagus nerve , circadian rhythm , stimulation , cardiology , respiratory rate , blood pressure , physics , astronomy
The power spectrum of heart rate variability contains low frequency (LF = 0.08–0.12 Hz) and high frequency (HF = 0.18–0.30 Hz) components said to represent neurocardiac rhythms. To verify whether such a relationship exists we report a unique study where the heart rate autospectrum was determined in a 28‐year‐old epileptic male patient with an implanted vagal electrical stimulator. The stimulator was activated at 20 Hz, 300 psec pulse, and 1.25 V. Continuous ECG and respiratory waveform records were obtained over 45 minutes every 8 hours (7–8 AM; 3–4 PM; 11–12 PM) With the stimulator ON, then 24 hours OFF and then 24 hours ON again. The overall LF:HF peak ratio increased from 0.64 to 1.99 (P < 0.001) after the stimulator was turned OFF. There was a dramatic increase in the LF peak power (> 60%) and a corresponding decrease in the HF peak power (> 65%) when the stimulator was turned OFF. These values were reversed when the stimulator was turned ON again. In the early morning and late evening hours, there was a significant rightward shift in the LF peak power frequency (average 0.057 to 0.075 Hz) whenever the stimulator was ON. Otherwise, there were no significant circadian variations in any of the autospectral components. The results demonstrate an unequivocal relationship between selective vagal nerve electro stimulation and alterations in the heart rate autospectrum.