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Autologous Skeletal Muscle, an Alternative for Cardiac Assistance
Author(s) -
RUGGIERO RENATO,
POCHETTINO ALBERTO,
HAMMOND ROBERT L.,
AMI HIROSHI NUN,
HUIPING LU,
SPANTA ALI D.,
STEPHENSON LARRY W.
Publication year - 1991
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1991.tb04097.x
Subject(s) - medicine , skeletal muscle , cardiac muscle , heart failure , cardiology , cardiomyoplasty , diastole , hemodynamics , physical medicine and rehabilitation , blood pressure
Original attempts to use skeletal muscle for cardiac assistance were soon abandoned when the problem of muscle fatigue could not be solved. In the last 2 decades, better understanding of muscle physiology and the development of successful protocols of electrical muscle conditioning have given new impetus to researchers around the world to proceed in the effort to identify useful applications of skeletal muscle to support the heart. More than 100 patients around the world have undergone cardiomyoplasty, mostly for cardiac failure. While subjective improvement in symptoms was noticed in the majority of the patients, only recently favorable hemodynamic changes have been documented. The other alternative that has been pursued in the laboratory is the construction of skeletal muscle ventricles that, after conditioning and vascular delay, have been shown to provide significant cardiac support when used for diastolic counterpulsation or for right heart bypass in animal models.