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Bradycardia and Syncope in Children Not Controlled by Pacing: Beta‐Adrenergic Hypersensitivity
Author(s) -
PERRY JAMES C.,
FRIEDMAN RICHARD A.,
MOAK JEFFREY P.,
GARSON ARTHUR
Publication year - 1991
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1991.tb04084.x
Subject(s) - medicine , bradycardia , syncope (phonology) , beta (programming language) , cardiac pacing , anesthesia , cardiology , adrenergic receptor , adrenergic , heart rate , blood pressure , receptor , computer science , programming language
Cardiac pacing is frequently employed in the therapy of children with syncope and documented bradycardia. This report describes two children, ages 7 and 9 years, who underwent placement of demand ventricular pacing systems for documented bradycardia and syncope. Cardiac cathe‐terization and intracardiac electrophysiological studies failed to show evidence of structural abnormalities, sinus node or conduction system disease, inducible arrhythmias, or VA conduction in each patient. Both patients had persistent symptoms after pacemaker implantation. Autonomic function testing with continuous heart rate and blood pressure monitoring revealed exaggerated beta‐adrenergic responses to simple standing and small doses of isoproterenol. Symptoms were completely eliminated with atenolol. In these two children, cardiac pacing alone was not adequate for relief of symptoms. Autonomic mechanisms of bradycardia and hypotension should be considered prior to implantation of permanent pacing systems in children.