Premium
Which Factors Determine the Development of Late Potentials After First Myocardial Infarction? A Multifactorial Analysis
Author(s) -
MCCLEMENTS BRIAN,
ADGEY A. A. JENNIFER,
MACKENZIE GILBERT
Publication year - 1991
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1991.tb02805.x
Subject(s) - medicine , myocardial infarction , cardiology
A multifactorial analysis was performed to study the factors that contributed to the occurrence of late potentials on the signal‐averaged electrocardiogram in 106 consecutive patients with a first myocardial infarction. Ninety‐three (88%) patients received intravenous thrombolytic therapy within 6 hours of symptom onset. Thirty‐two (30%) patients had a late potential on the signal‐averaged electrocardiogram on day 6, including 17 of 31 (55%) in whom the infarct‐related artery was occluded and 15 of 75 (20%) in whom it was patent (P = 0.0004). Twenty‐three variables were analyzed by a multifactorial stepwise regression analysis. Predictors of a late potential were (1) an occluded infarct‐related coronary artery (t = ‐3.653, P = 0.0004) and (2) the extent of myocardial necrosis as indicated by the peak serum lactate dehydrogenase level (t = 3.094, P = 0.0025). The lower incidence of late potentials when the infarct‐related coronary artery was patent was independent of left ventricular election fraction and peak enzyme levels after infarction.