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Complex Rhythms Resulting From Overdrive Suppression in Electrically Stimulated Heart Cell Aggregates
Author(s) -
WANZHEN ZENG,
MORISSETTE JOSÉE,
BROCHU RICHARD,
GLASS LEON,
SHRIER ALVIN
Publication year - 1990
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1990.tb06871.x
Subject(s) - rhythm , stimulation , bursting , beat (acoustics) , medicine , heart rate , neuroscience , heart rhythm , biophysics , physics , biology , optics , blood pressure
WANZHEN, Z., ET AL.: Complex Rhythms Resulting From Overdrive Suppression in Electrically Stimulated Heart Cell Aggregates. Spontaneously beating embryonic chick heart cell aggregates were stimulated with current pulses delivered either as periodic trains, or at a fixed delay after each action potential. Following Stimulation at fixed rates faster than the intrinsic rate, there was a transient slowing of the spontaneous rhythm. This response, called overdrive suppression, can lead to a complex evolution of rhythms. During periodic stimulation there is a continuum of dropped beat patterns, and during fixed delay stimulation bursting activity appears. This study provides a conceptual basis for understanding analogous rhythms in the intact heart.