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Directional Variability of Stimulation Threshold Measurements in Isolated Guinea Pig Cardiomyocytes: Relationship with Orthogonal Sequential Defibrillating Pulses
Author(s) -
BARDOU ALAIN L.,
CHESNAIS JEANMICHEL,
BIRKUI PIERRE J.,
GOVAERE MARIECLAUDE,
AUGER PIERRE M.,
EUW DOMINIQUE VON,
DEGONDE JEAN
Publication year - 1990
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1990.tb06859.x
Subject(s) - stimulation , defibrillation threshold , medicine , electric field , pulse (music) , defibrillation , transverse plane , guinea pig , orientation (vector space) , cardiology , biomedical engineering , nuclear magnetic resonance , anatomy , voltage , physics , mathematics , geometry , quantum mechanics
BARDOU A.L., ET AL.: Directional Variability of Stimulation Threshold Measurements in Isolated Guinea Pig Cardiomyocytes: Relationship with Orthogonal Sequential Defibrillating Pulses. Reports on delivery of separated orthogonal pulses markedly improving cardiac defibrillation have suggested that the stimulation threshold of heart fibers varies in accordance with their orientation within the electric field. The present work was aimed at investigating the directional variability of stimulation thresholds in isolated guinea pig cardiomyocytes. This variability was measured in 48 single myocytes by rotating each one through a theta (θ) angle between two‐fixed parallel electrodes 1.1 cm apart, thus making θ vary between the electric field and the myocyte axis. For θ= 0°, the mean longitudinal current stimulation threshold was 16.92 ± 4.20 mA (n = 48). When θ was increased by increments of 10° up to 90°, the stimulation threshold increased in an exponential way. For θ= 90°, the mean transverse stimulation threshold was 63.23 ± 13.30 mA. These results clearly demonstrate the dependence of isolated cardiomyocyte stimulation thresholds on their orientation within the electric field and may account for the improved efficacy of defibrillation previously observed after delivery of orthogonal pulses.