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DL and D Sotalol Decrease Defibrillation Energy Requirements
Author(s) -
WANG MICHELE,
DORIAN PAUL
Publication year - 1989
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1989.tb06157.x
Subject(s) - medicine , sotalol , defibrillation , energy requirement , cardiology , anesthesia , atrial fibrillation , psychology , regression , psychoanalysis
We examined the acute effects of intravenous DL and D sotalol on the energy requirements for internaJ defibrillation (DF) in 44 dogs anesthetized with pentobarbital (n = 18), enflurane (n = B), and fentanyl (n = 18). Multiple shocks of varying energies were applied through left and right ventricular epicardial patch electrodes to relate delivered energy to percent success in DF. The energies required for 50% success in DF (E) were estimated by logistic regression. DL or D sotalol was administered in a loading (4 mg/kg over 10 min) and maintenance (1.5 mg/kg/hr) infusion and the energy—success curve was again measured 30 minutes after drug administralion. The effect of DL and D sotalol on E 50 was compared to controls given saline. Both DL and D sotalol significantly lowered E 50 by 16%± 14% (P < 0.05) and 24.5%± 8.2% (P < 0.05), respectively, in fentanyl anesthetized animals; this was accompanied by a 22%± 8% (P < 0.05) and 16%± 5% (P < 0.01) increase in ventricular elective refractory period (VERP), respectively. In pentobarbital anesthetized dogs, DL and D sotalol decreased E 50 by 16%± 27% (P = ns) and 11%± 16% (P < 0.05), respectively, and were associated with a 23%± 5% (P < 0.01) and 12 ± 4% (P < 0.05) prolongation of VERP. DL and D sotalol decrease defibrillation energy requirements, possibly as a result of their Class III antiarrhythmic drug action.