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Efficacy and Safety of Rate Responsive Pacing in Patients with Coronary Artery Disease and Angina Pectoris
Author(s) -
COCK CAREL C.,
PANIS JAN H.C.,
EENIGE MACHIEL J.,
ROOS JAN P.
Publication year - 1989
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1989.tb05055.x
Subject(s) - medicine , angina , cardiology , coronary artery disease , heart rate , blood pressure , anesthesia , myocardial infarction
The present study included 17 patients with angina pectoris and coronary artery disease in whom a rate responsive ventricular pacemaker (Medtronic Activitrax) had been implanted. All patients had an exclusively paced rhythm. Single blinded, random, cross‐over treadmill tests in the rate responsive pacing mode (VVIR) and in the fixed‐rate demand mode (VVI) were performed, with an interval of 4–6 weeks. Mean exercise duration increased by 25% during VVIR pacing. Maximal heart rate increased significantly during VVIR compared to VVI pacing (VVI = 74 ± 2 bpm, VVIR = 116 ± 8 bpm, P < 0.001) as did the rate‐pressure product (VVI = 10.850 ± 1,124, VVIR = 16.628 ± 2,110, P < 0.001). Despite improved performance, the number of anginal attacks per week and the nitroglycerin consumption did not show a significant difference between the two pacing modes. It is concluded that rate responsive pacing is beneficial and safe in patients with angina pectoris and coronary artery disease.