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Long‐Term Neurostimulation of Skeletal Muscle: Its Potential for a Tether‐Free Biologic Cardiac Assist Device
Author(s) -
ANDERSON WILLIAM A.,
BRIDGES CHARLES R.,
CHIN ALVIN J.,
ANDERSEN JAMES S.,
ACKER MICHAEL A.,
HAMMOND ROBERT L.,
DIMEO FREDERICK,
CAHALAN PATRICK T.,
GALE DENNIS R.,
BROWN WENDY E.,
STEPHENSON LARRY W.
Publication year - 1988
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1988.tb06361.x
Subject(s) - skeletal muscle , medicine , neurostimulation , cardiology , stimulation
Skeletal muscle has a tremendous capacity to adapt. This adaptive phenomenon is seen perhaps to the greatest extent when skeletal muscle is subjected to chronic low frequency stimulation via the motor nerve. There is a decrease in glycolytic enzymes and an increase in oxidotive enzymes, as well as a change in the contractile proteins and an increase in the mitochondrial volume fraction of the muscle fiber. These adaptive changes result in a muscle that is considerably more fatigue‐resistant. Specifically herein, we report on a pneumatic aortic counterpulsator device powered by skeletal muscle. These muscle pumps functioned continuously and pumped blood effectively in tether‐free animals for several weeks.