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Mathematical Descriptions of AV Nodal Function Curves in Dogs
Author(s) -
CHORRO FRANCISCO J.,
RUIZCRANELL RICARDO,
CASADAN ERNESTO,
CARCIACIVERA ROBERTO,
SUCH LUIS,
LOPEZMERINO VICENTE
Publication year - 1988
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1988.tb06017.x
Subject(s) - exponential function , nonlinear system , medicine , residual , function (biology) , mathematical analysis , thermal conduction , hyperbolic function , nodal , mathematics , anatomy , algorithm , thermodynamics , physics , quantum mechanics , evolutionary biology , biology
Thirty‐four anaestheized mongrel dogs subjected to thoracotomy were used to study AV node conduction during atrial pacing at increasing rates. Eplcardial atrial electrodes were used, together with endocavitary recordings of His bundle electrogram. An analysis was made of the repercussions involved in using four different mathematical functions describing nodal conduction; three were nonlinear (exponential and hyperbolic A and B) and one linear. In the case of the first three, the consequences of using a direct nonlinear data‐fitting procedure or an indirect procedure by linear transformations of the functions were studied. The exponential and hyperbolic B functions provided the least mean squared residual in quantifying nodal conduction (8.6 ± 10.8 ms 2 and 10.8 ± 13.9 ms 2 , respectively). The use of nonlinear function transformation into a linear representation caused Joss of precision in the fit to the data in the case of the exponential function (18.3 ± 22.2 ms 2 versus 8.Q ± 10.8 ms 2 , p < 0.01] and, to a lesser extent, in the case of the hyperbolic B function [12.5 ± 16.4 ms 2 versus 10.8 ± 13.9 ms 2 , P < 0.05).