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Antibodies to Human Sinus Node in Sick Sinus Syndrome
Author(s) -
MAISCH BERNHARD,
LOTZE ULRICH,
SCHNEIDER JAKOB,
KOCHSIEK KURT
Publication year - 1986
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1986.tb06677.x
Subject(s) - sss* , medicine , sick sinus syndrome , sinus (botany) , antibody , cardiology , autoantibody , incidence (geometry) , myocarditis , heart disease , immunology , physics , optics , biology , genus , botany
The incidence of autoantibodies against human conducting tissue was studied in 45 pacemaker patients with sick sinus syndrome (SSS), in 17 patients with bradyarrhythmia, and jive patients with hypertensitive carotid sinus syndrome. Antibodies against the human sinus node were demonstrated in 29% of patients with SSS and in 24% of patients with bradyarrhythmia; a tenfold risk of SSS could be calculated in patients with this antibody as compared to age‐matched controls. At least two subtypes of anti‐sinus node antibodies were demonstrated: an antibody absorbable and another one not absorbable with ventricular myocardium. Patients with SSS and prior myocarditis of rheumatic fever have a threefold incidence of that antibody, demonstrating that anti‐conducting tissue antibodies are etiologic indicators for former inflammatory heart disease. These antibodies may play a role in the secondary immunopathogenesis of sick sinus syndrome. This hypothesis emerges as an interesting new pathogenetic concept.