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Torsades de Pointes Due to N‐Acetylprocainamide
Author(s) -
STEVENSON WILLIAM G.,
WEISS JAMES
Publication year - 1985
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1985.tb05854.x
Subject(s) - procainamide , medicine , torsades de pointes , qt interval , napa , cardiology , anesthesia , genetics , biology
A 66‐year‐old female with chronic renal failure received five doses of procainamide and developed marked QT interval prolongation and recurrent episodes of torsades de pointes. which were temporally related to high serum n‐acetylprocainamide (NAPA) levels and not to procainamide levels. Repeated hemodialysis was effective in lowering NAPA levels. Torsades de pointes is a potential hazard of NAPA accumulation during procainamide administration to patients with renal insufficiency.