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Amiodarone: Individualizing Dosage with Serum Concentrations
Author(s) -
ROTMENSCH HESCHI H.,
SWANSON BRIAN N.,
GREENSPON ARNOLD J.,
SHOSHANI DAVID,
GREENSPAN ALLAN M.
Publication year - 1983
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1983.tb04475.x
Subject(s) - amiodarone , medicine , serum concentration , pharmacokinetics , pharmacology , maintenance dose , intensive care medicine , atrial fibrillation
The purpose of the present report is to review the available pharmacokinetic informaation on amiodarone with an emphasis on our own experience in monitoring serum amiodarone concentrations. We have found that 400 mg should be the maximal maintenance dose; if that treatment fails, careful addition of other antiarrhythmic agents is preferable over an increase in amiodarone dosage. Serum concentrations below 2.5 mg/L will significantly improve amiodarone's benefit‐to‐risk ratio.