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Sulfinpyrazone: An Antiarrhythmic Drug?
Author(s) -
ROOS JULIUS C.,
DUNNING AREND J.
Publication year - 1982
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1982.tb02241.x
Subject(s) - medicine , sulfinpyrazone , cardiology , flecainide , sudden death , anesthesia , intracardiac injection , drug , atrial fibrillation , pharmacology , aspirin
The patients were studied by intracardiac electrocardiography and programmed stimulation before and after an intravenous bolus injec tion of either 500 mg sulfinpyrazone or a placebo. We found no consistent clinical or statistical effects of sulfinpyrazone on sinus rate, sinus node recovery time, sinoatrial conduction time, conduction intervals during spontaneous cardiac activity and atrial pacing, Wenckebach point and refractory periods of the atrium, AV node, His Purkinje system and right ventricle. We conclude that sulfinpyra zone has no clinican electrophysiological effects comparable with those of known antiarrhythmic agents and that a direct antiarrhythmic action is an unlikely explanation for the reduction of sudden death in postinfarction patients treated with this drug. Antiarrhythmic activity by an indirect mecha nism, related to the antipaltelet properties of the drug, or by metabolites of sulfinpyrazone, remains a possibility requiring further investigation. PACE, VoJ. 5, May‐June, 1982)