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Evidence of Low‐Grade Intravascular Coagulation in Patients with Transvenous Pacemakers
Author(s) -
CHRISTOPOULOUCOKKINOU VANA,
KONTAXIS ARGYRIS,
MALLIOS CONSTANTINE,
VORIDES EUTYCHIOS M.,
COKKINOS DENNIS V.
Publication year - 1982
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1982.tb02240.x
Subject(s) - medicine , intracardiac injection , fibrinogen , surgery , cardiology , subclinical infection , thrombosis , anesthesia , gastroenterology
Serum fibrin and fibrinogen degradation products (FDP) were measured in 4 groups of patients. In Group A (30 patients) FDP levels were measured before and 48–60 hours after pacemaker and transvenous electrode placement. They remained negative (< 10 μg/ml) in 14, rose to > 10μg/ml < 40μyg/ml in 12, and > 40 μg/ml in 4. In 12 Group B patients undergoing the same procedure, FDP levels remained negative in 8, and rose in 4 after 24 hours and after 7 days. In 12 Group C patients sludied at initial electrode and battery implantation and 3‐6 months later, there were the same results in short‐ and long‐term FDP measurements (8 negative and 4 elevated). Finally, in 14 patients with negative FDP levels who underwent battery replacement only. 3.1 to 5.2 years after their in itial operation (Group D, no increase of FDP titer was seen postoperatively. Our results suggest that elevated FDP levels suggest subclinical intravenous or intracardiac thrombosis in patients with trans venous pacemakers. (PACE, Vol. 5, May‐June, 1982)