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Electrophysiologic Properties of Hydralazine in Man
Author(s) -
GOULD LAWRENCE,
REDDY C.V. RAMANA,
ZEN B.,
SINGH B.K.,
BECKER WILLIAM H.
Publication year - 1980
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.1980.tb05274.x
Subject(s) - medicine , hydralazine , phentolamine , cardiology , preload , afterload , myocardial infarction , heart failure , anesthesia , thermite , hemodynamics , propranolol , blood pressure , aluminium , chemistry , organic chemistry
There is considerable interest in selecting the proper drug to preserve the ischemic myocardium, or twilight zone, in a patient with a recent myocardial infarction, Vasodilator therapy with an infusion of nitroprusside 1 or phentolamine 2,3 has been shown to improve left ventricular function by reducing both preload and afterload. Sublingual nitroglycerin 4 as well as an infusion of nitroglycerin 5 can also alleviate left ventricular failure in patients with an acute myocardial infarction. Similarly, chronic congestive heart failure patients, irrespective of the etiology, improve hemodynam‐ically after an infusion of phentolamine, 6,7 nitroprusside 8 or hydralazine. 9 Oral nitrates, 10 phentolamine, 11 and hydralazine 12 have also been demonstrated to produce improvement in chronic heart failure patients. Recently data has become available on the effects of phentolamine. 13 nitroglycerin 14 and nitroprusside 15 on cardiac conduction in man. However there is no information on the electrophysiological properties of hydralazine in man. The present study involving 12 human subjects was undertaken lo determine what effect iniravenously administered hydralazine has on the human conduction system.