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Benzene Risk Estimation Using Radiation Equivalent Coefficients
Author(s) -
Nakayama Aki,
Isono Tomomi,
Kikuchi Takuro,
Ohnishi Iichiro,
Igarashi Junichiro,
Yoneda Minoru,
Morisawa Shinsuke
Publication year - 2009
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.2008.01174.x
Subject(s) - benzene , equivalent dose , physiologically based pharmacokinetic modelling , linear regression , statistics , radiation , range (aeronautics) , mathematics , analytical chemistry (journal) , nuclear medicine , toxicology , dosimetry , chemistry , materials science , chromatography , medicine , physics , pharmacokinetics , optics , biology , organic chemistry , pharmacology , composite material
We estimated benzene risk using a novel framework of risk assessment that employed the measurement of radiation dose equivalents to benzene metabolites and a PBPK model. The highest risks for 1 μg/m 3 and 3.2 mg/m 3 life time exposure of benzene estimated with a linear regression were 5.4 × 10 −7 and 1.3 × 10 −3 , respectively. Even though these estimates were based on in vitro chromosome aberration test data, they were about one‐sixth to one‐fourteenth that from other studies and represent a fairly good estimate by using radiation equivalent coefficient as an “internal standard.”