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The EPA Health Risk Assessment of Methylcyclopentadienyl Manganese Tricarbonyl (MMT)
Author(s) -
Davis J. Michael,
Jarabek Annie M.,
Mage David T.,
Graham Judith A.
Publication year - 1998
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1998.tb00916.x
Subject(s) - risk assessment , health risk assessment , environmental science , gasoline , inhalation exposure , exposure assessment , environmental health , health risk , manganese , environmental chemistry , risk analysis (engineering) , inhalation , computer science , engineering , waste management , chemistry , medicine , computer security , anatomy , organic chemistry
This paper describes the U.S. Environmental Protection Agency's assessment of potential health risks associated with the possible widespread use of a manganese (Mn)‐based fuel additive, methylcyclopentadienyl manganese tricarbonyl (MMT). This assessment was significant in several respects and may be instructive in identifying certain methodological issues of general relevance to risk assessment. A major feature of the inhalation health risk assessment was the derivation of Mn inhalation reference concentration (RfC) estimates using various statistical approaches, including benchmark dose and Bayesian analyses. The exposure assessment component used data from the Particle Total Exposure Assessment Methodology (PTEAM) study and other sources to estimate personal exposure levels of particulate Mn attributable to the permitted use of MMT in leaded gasoline in Riverside, CA, at the time of the PTEAM study; on this basis it was then possible to predict a distribution of possible future exposure levels associated with the use of MMT in all unleaded gasoline. Qualitative as well as quantitative aspects of the risk characterization are summarized, along with inherent uncertainties due to data limitations.