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A Nonidentifiability Aspect of the Two‐Stage Model of Carcinogenesis
Author(s) -
Hanin Leonid G.,
Yakovlev Andrej Yu.
Publication year - 1996
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1996.tb00819.x
Subject(s) - identifiability , carcinogenesis , homogeneous , stage (stratigraphy) , mathematics , statistical physics , statistics , biology , genetics , physics , cancer , paleontology
This paper discusses identifiability of the two‐stage birth‐death‐mutation model of carcinogenesis. It is shown that the homogeneous version of the model is nonidentifiable; the same is all the more evident for its nonhomogeneous versions. This result implies that the model parameters cannot be uniquely estimated from time‐to‐tumor observations.