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Estimation of Acute Toxicity by Fitting a Dose‐Time‐Response Surface
Author(s) -
Sun Kai,
Krause Gary F.,
Mayer Foster L.,
Ellersieck Mark R.,
Basu Asit P.
Publication year - 1995
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1995.tb00318.x
Subject(s) - acute toxicity , toxicity , exposure duration , fish <actinopterygii> , statistics , aquatic toxicology , biological system , data set , chemical toxicity , experimental data , toxicology , computer science , mathematics , biology , chemistry , fishery , organic chemistry
In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose‐response curve, and the time course of effect is usually ignored for lack of a suitable model. A model which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. The proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. The new statistical technique is also tested by a data base of a variety of chemical and fish species.