Premium
Armitage‐Doll Two‐Stage Model: Implications and Extension
Author(s) -
Chen Chao W.
Publication year - 1993
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1993.tb01079.x
Subject(s) - stage (stratigraphy) , constant (computer programming) , multi stage , computer science , geology , engineering , industrial engineering , paleontology , programming language
The objective of this paper is twofold: (1) to provide insight on the simplified MVK model of carcinogenesis (a model proposed by Moolgavkar and colleagues) by revealing the relationship between the Armitage‐Doll two‐stage model and the simplified MVK model; and (2) to extend the Armitage‐Doll two‐stage model to one with time‐varying (piece‐wise constant) parameters. It is shown that the simplified MVK model is a special case of the Armitage‐Doll two‐stage model, and many applications of the simplified MVK model involving intermittent exposures or exposures to different compounds in different time periods can be derived easily from the Armitage‐Doll two‐stage model with piece‐wise constant parameters. The limitations of the Armitage‐Doll two‐stage model are discussed.