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How Tautological Are Interspecies Correlations of Carcinogenic Potencies?
Author(s) -
Freedman David A.,
Gold Lois Swirsky,
Slone Thomas H.
Publication year - 1993
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1993.tb01078.x
Subject(s) - artifact (error) , extrapolation , correlation , carcinogen , positive correlation , econometrics , statistics , toxicology , computational biology , chemistry , mathematics , biology , genetics , medicine , neuroscience , geometry
Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al. , however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. have a comeback. This paper will review the arguments and present some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al.