Premium
Two‐Event Model for Carcinogenesis: Biological, Mathematical, and Statistical Considerations
Author(s) -
Moolgavkar Suresh H.,
Luebeck Georg
Publication year - 1990
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1990.tb01053.x
Subject(s) - carcinogenesis , experimental data , radon , event (particle physics) , statistical model , computer science , econometrics , computational biology , statistics , mathematics , biology , cancer , genetics , physics , quantum mechanics
A two‐mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time‐dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors.