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Risk Assessment for Aflatoxin: I. Metabolism of Aflatoxin B 1 by Different Species
Author(s) -
Gorelick Nancy J.
Publication year - 1990
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1990.tb00538.x
Subject(s) - aflatoxin , carcinogen , detoxification (alternative medicine) , mycotoxin , biology , in vitro , in vitro toxicology , in vivo , biochemistry , chemistry , food science , genetics , medicine , alternative medicine , pathology
A comparison of the generation and detoxification of reactive aflatoxin B 1 metabolites in different species may elucidate why animal species vary widely in sensitivity to aflatoxin B 1 carcinogenicity, in addition to offering some perspective on how sensitive man may be to the carcinogenic effects of this mycotoxin. Scientific literature comparing the ability of cellular fractions from different species to metabolize aflatoxin B 1 is reviewed. However, in vitro studies exclude components for multiple metabolic pathways, eliminating the possibility of competition between metabolic activation and detoxification. Quantification of metabolic activation by different species from these studies is therefore limited. The species‐specific carcinogenic potency of aflatoxin B 1 may be reflected in levels of aflatoxin B 1 ‐DNA adducts generated in vivo. The current paucity of quantitative information on human DNA adduct levels does not permit comparision between different species on this basis.