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Dermal Uptake of Organic Chemicals from a Soil Matrix
Author(s) -
McKone Thomas E.
Publication year - 1990
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1990.tb00524.x
Subject(s) - stratum corneum , partition coefficient , dimensionless quantity , deposition (geology) , environmental chemistry , chemistry , human skin , octanol , matrix (chemical analysis) , soil science , environmental science , chromatography , thermodynamics , geology , medicine , paleontology , physics , genetics , pathology , sediment , biology
Uptake of chemicals from soil on human skin is considered. Based on a review of literature on the structure of human skin, the processes by which chemicals pass through this boundary, and experiments that reveal the rate and magnitude of this transport process; a two‐layer model is presented for estimating how chemical uptake through the stratum corneum depends on chemical properties, skin properties, soil properties and exposure conditions. The model is applied to two limiting scenarios—(1) continuous deposition and removal of soil on the skin surface and (2) a one‐time deposition of soil onto the skin surface. The fraction of soil‐bound chemical that passes through the stratum corneum is dependent on the skin‐soil layer thickness; the dimensionless Henry's law constant, K h and the octanol‐water partition coefficient, K ow of the soil‐bound chemical. The nature of this dependence is discussed.