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Evaluation of Developmental Toxicity Data: A Discussion of Some Pertinent Factors and a Proposal
Author(s) -
Hart William L.,
Reynolds Ralph C.,
Krasavage Walter J.,
Ely Thomas S.,
Bell R. Hays,
Raleigh Robert L.
Publication year - 1988
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1988.tb01154.x
Subject(s) - developmental toxicity , hazard , hazard analysis , data quality , quality (philosophy) , computer science , risk assessment , interpretation (philosophy) , risk analysis (engineering) , reliability engineering , engineering , biology , medicine , computer security , operations management , ecology , philosophy , epistemology , programming language , pregnancy , metric (unit) , genetics , gestation
There is currently no well‐accepted standard method for evaluation of developmental toxicity data. This paper presents one approach to the evaluation of developmental toxicity data. We initially identify some pertinent factors that influence the interpretation of animal data and summarize the literature pertaining to these factors. Such factors include the quality and quantity of data and the relationship between maternal and developmental toxicity. We proceed with a discussion of quantitative assessment of data and propose schemes for qualitative and quantitative developmental hazard assessments.