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A Stochastic Two‐Stage Model for Cancer Risk Assessment. I. The Hazard Function and the Probability of Tumor
Author(s) -
Moolgavkar Suresh H.,
Dewanji Anup,
Venzon David J.
Publication year - 1988
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1988.tb00502.x
Subject(s) - hazard , stage (stratigraphy) , function (biology) , stochastic modelling , statistics , risk assessment , econometrics , mathematics , computer science , biology , genetics , ecology , paleontology , computer security
We present a mathematical treatment of a two‐mutation model for carcinogenesis with time‐dependent parameters. This model has previously been shown to be consistent with epidemiologic and experimental data. An approximate hazard function used in previous papers is critically evaluated.