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Multistage Model Interpretation of Additive and Multiplicative Carcinogenic Effects 1
Author(s) -
Gibb Herman J.,
Chen Chao W.
Publication year - 1986
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1986.tb00204.x
Subject(s) - carcinogen , multiplicative function , interpretation (philosophy) , chemistry , toxicology , mathematics , computer science , biochemistry , biology , mathematical analysis , programming language
Under the assumption of multistage carcinogenesis, a multiplicative carcinogenic effect would be produced by the action of different carcinogens in a mixture on different stages of the carcinogenic process. An additive effect would be produced by the effect of different carcinogens on the same stage. A mathematical argument for these hypotheses is presented here.