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Ambiguous Carcinogens and Their Regulation 1
Author(s) -
Weinberg Alvin M.,
Storer John B.
Publication year - 1985
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1985.tb00162.x
Subject(s) - carcinogen , incidence (geometry) , leukemia , cancer , lymphoma , ambiguity , toxicology , environmental health , medicine , biology , biochemistry , computer science , mathematics , geometry , programming language
Examination of five animal and one human studies suggest that certain agents increase the incidence of some cancers but simultaneously reduce the incidence of other cancers. Yellow die 3, for example, sharply increases the incidence of liver tumors but practically eliminates naturally occurring leukemia/lymphoma in F‐344 male rates. Such ambiguity in the action of presumed carcinogens suggests that caution must be used by regulatory bodies in proscribing suspected carcinogens, or even in recommending changes in lifestyle or dietary habits as a means of reducing incidence of cancer.