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Use of Acute Toxicity to Estimate Carcinogenic Risk
Author(s) -
Zeise Lauren,
Wilson Richard,
Crouch Edmund
Publication year - 1984
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1984.tb00138.x
Subject(s) - interim , estimation , risk assessment , risk analysis (engineering) , carcinogen , environmental health , computer science , business , engineering , medicine , biology , geography , computer security , archaeology , systems engineering , genetics
Data on the effects of human exposure to carcinogens are limited, so that estimation of the risks of carcinogens must be obtained indirectly. Current risk estimates are generally based on lifetime animal bioassays which are expensive and which take more than two years to complete. We here show how data on acute toxicity can be used to make a preliminary estimate of carcinogenic risk and give an idea of the uncertainty in that risk estimate. The estimates obtained are biased upwards, and so are useful for setting interim standards and determining whether further study is worthwhile. A general scheme which incorporates the use of such estimates is outlined, and it is shown by example how adoption of the procedures suggested could have prevented regulatory hiatus in the past.