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Estimation and Extrapolation of Tumor Probabilities from a Mouse Bioassay with Survival/Sacrifice Components
Author(s) -
Farmer John H.,
Kodell Ralph L.,
Gaylor David W.
Publication year - 1982
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1982.tb01400.x
Subject(s) - bioassay , extrapolation , estimator , nonparametric statistics , statistics , toxicology , mathematics , biology , genetics
A nonparametric estimator of the probability distribution of time‐to‐tumor is incorporated into an algorithm for calculating linearly extrapolated dosage limits from an animal carcino‐genesis bioassay. The procedure is illustrated with tumor data from a mouse bioassay with 2‐acetylaminofluorene. Extrapolated dosage limits for an excess risk of 10 ‐6 differ by only a factor of 2 across the six replicates of the experiment.