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Some Problems in Determining Risks from Cancer
Author(s) -
Totter John R.
Publication year - 1982
Publication title -
risk analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.972
H-Index - 130
eISSN - 1539-6924
pISSN - 0272-4332
DOI - 10.1111/j.1539-6924.1982.tb01399.x
Subject(s) - cancer , incidence (geometry) , selection (genetic algorithm) , medicine , demography , cancer incidence , resistance (ecology) , environmental health , biology , mathematics , ecology , computer science , geometry , artificial intelligence , sociology
Age‐adjusted cancer mortality data (1964) were examined for evidence of independence. Indications were found that substitution of one cancer for another is a common occurrence. The data were interpreted as supportive of the view that natural selection for resistance to cancer in general has occurred with many resistance‐related genes common to prevention of cancer of several sites. Consequently, the comparison of age‐adjusted incidence or mortality rates of cancer of single sites alone does not provide a satisfactory estimate of the magnitude of an “environmentally induced” cancer risk. It is necessary to examine all causes of death to find indications of a real life‐shortening episode.