Premium
Long‐term outcomes of patients with cerebral vein thrombosis: a multicenter study
Author(s) -
DENTALI F.,
POLI D.,
SCODITTI U.,
MINNO M. N. D. DI,
STEFANO V. D.,
SIRAGUSA S.,
KOSTAL M.,
PALARETI G.,
SARTORI M. T.,
GRANDONE E.,
VEDOVATI M. C.,
AGENO W.
Publication year - 2012
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2012.04774.x
Subject(s) - medicine , hazard ratio , deep vein , confidence interval , thrombosis , surgery , retrospective cohort study , incidence (geometry) , cohort , cohort study , proportional hazards model , venous thrombosis , physics , optics
Summary. Background: Little information is available on the long‐term clinical outcome of cerebral vein thrombosis (CVT). Objectives and methods: In an international, retrospective cohort study, we assessed the long‐term rates of mortality, residual disability and recurrent venous thromboembolism (VTE) in a cohort of patients with a first CVT episode. Results: Seven hundred and six patients (73.7% females) with CVT were included. Patients were followed for a total of 3171 patient‐years. Median follow‐up was 40 months (range 6, 297 months). At the end of follow‐up, 20 patients had died (2.8%). The outcome was generally good: 89.1% of patients had a complete recovery (modified Rankin Score [mRS] 0–1) and 3.8% had a partial recovery and were independent (mRS 2). Eighty‐four per cent of patients were treated with oral anticoagulants and the mean treatment duration was 12 months. CVT recurred in 31 patients (4.4%), and 46 patients (6.5%) had a VTE in a different site, for an overall incidence of recurrence of 23.6 events per 1000 patient‐years (95% confidence Interval [CI] 17.8, 28.7) and of 35.1 events/1000 patient‐years (95% CI, 27.7, 44.4) after anticoagulant therapy withdrawal. A previous VTE was the only significant predictor of recurrence at multivariate analysis (hazard ratio [HR] 2.70; 95% CI 1.25, 5.83). Conclusions: The long‐term risk of mortality and recurrent VTE appears to be low in patients who survived the acute phase of CVT. A previous VTE history independently predicts recurrent events.