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Relationship between paraoxonase‐1 activity, its Q192R genetic variant and clopidogrel responsiveness in the ADRIE study
Author(s) -
FONTANA P.,
JAMES R.,
BARAZER I.,
BERDAGUÉ P.,
SCHVED J.F.,
REBSAMEN M.,
VUILLEUMIER N.,
RENY J.L.
Publication year - 2011
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2011.04409.x
Subject(s) - clopidogrel , cyp2c19 , cytochrome p450 , pharmacology , active metabolite , ticlopidine , metabolite , prodrug , medicine , pon1 , p2y12 , chemistry , biochemistry , gene , metabolism , myocardial infarction , genotype
*Division of Angiology and Hemostasis, Division of Endocrinology, Diabetology and Nutrition, Department of Medical Specialties, GenevaUniversity Hospitals and Faculty of Medicine, Geneva, Switzerland; Hematology Laboratory, §Division of Cardiology, Be´ziers Hospital, Be´ziers;–Hematology Laboratory, Montpellier University Hospital, Montpellier, France; **Division of Laboratory Medicine, Department of Genetics andLaboratory Medicine, Geneva University Hospitals, Geneva; and Division of General Internal Medicine, Geneva University Hospital and Facultyof Medicine, Geneva, SwitzerlandTo cite this article: Fontana P, James R, Barazer I, Berdague´ P, Schved JF, Rebsamen M, Vuilleumier N, Reng JL. Relationship betweenparaoxonase-1 activity, its Q192R genetic variant and clopidogrel responsiveness in the ADRIE study. J Thromb Haemost 2011; 9: 1664–6.