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Exploration of the host haemostatic system by group A streptococcus: implications in searching for novel antimicrobial therapies
Author(s) -
SUN H.
Publication year - 2011
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2011.04316.x
Subject(s) - antimicrobial , host (biology) , streptococcus , group a , microbiology and biotechnology , streptococcus pyogenes , medicine , biology , bacteria , genetics , staphylococcus aureus
Summary. The haemostatic system is heavily involved in the host response to infection. A number of host haemostatic factors, notably plasminogen and fibrinogen have been reported to bind and interact with various bacterial proteins. This review summarises the roles of host haemostatic factors such as plasminogen, factor V and fibrinogen in host defence against group A streptococcus infection and discusses the potential of targeting the host haemostatic system for therapeutic intervention against infectious diseases.