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Lessons from genome‐wide association studies in venous thrombosis
Author(s) -
MORANGE P. E.,
TREGOUET D. A.
Publication year - 2011
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2011.04311.x
Subject(s) - genome wide association study , genetic association , biology , genetics , medicine , bioinformatics , computational biology , single nucleotide polymorphism , genotype , gene
Summary. From the first genome wide association studies (GWAS) conducted on age‐related macular degeneration back in 2005 until now, hundreds of studies have applied this strategy to identify novel genetic loci associated with hundreds of human diseases and related quantitative risk factors. While the GWAS revolution has just started to shift towards the next generation sequencing’s burst, it is important to illustrate how the genetics research in venous thrombosis has benefit from the GWAS paradigm.