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Blood‐induced joint disease: the pathophysiology of hemophilic arthropathy
Author(s) -
VALENTINO L. A.
Publication year - 2010
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2010.03962.x
Subject(s) - medicine , arthropathy , osteoarthritis , rheumatoid arthritis , hemarthrosis , joint disease , arthritis , complication , pathogenesis , degenerative disease , deformity , joint pain , disease , surgery , pathology , immunology , alternative medicine
Summary. Arthropathy is a frequent and serious complication of repeated joint bleeding in patients with hemophilia, resulting in pain, deformity, and disability. Although the pathogenesis of hemophilic arthropathy has not been fully elucidated, it appears to have similarities with the degenerative joint damage that occurs in osteoarthritis and the inflammatory processes associated with rheumatoid arthritis. This article reviews the potential actions of various blood constituents on joint components that culminate in the development of hemophilic arthropathy.