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Lower coated‐platelet levels are associated with early hemorrhagic transformation in patients with non‐lacunar brain infarction
Author(s) -
PRODAN C. I.,
STONER J. A.,
COWAN L. D.,
DALE G. L.
Publication year - 2010
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2010.03851.x
Subject(s) - interquartile range , medicine , platelet , stroke (engine) , platelet activation , lacunar stroke , cardiology , population , cerebral infarction , gastroenterology , ischemic stroke , ischemia , mechanical engineering , environmental health , engineering
Summary. Background : Coated‐platelets, representing a subset of platelets with procoagulant potential, are elevated in patients with non‐lacunar ischemic stroke and decreased in patients with spontaneous intracerebral hemorrhage. However, within the non‐lacunar patient population there are individuals with lower levels of coated‐platelets, which raises the possibility that these individuals would be susceptible to early hemorrhagic transformation (HT) of ischemic stroke. Objective : Because extremes in coated‐platelet potential may be associated with either thrombotic or hemorrhagic events, we undertook a pilot study to investigate whether there is an association between coated‐platelet production and the presence of early HT in patients with non‐lacunar ischemic stroke. Patients and methods : Coated‐platelet levels were determined in 115 consecutive eligible patients with a diagnosis of non‐lacunar ischemic stroke. Early HT was determined on CT scan examination and confirmed by MRI studies. The distribution of coated‐platelet levels was summarized using the median and interquartile range (25th–75th percentiles) and compared statistically between patients with and without early HT using the non‐parametric Wilcoxon rank sum test. Results : The median coated‐platelet level in all non‐lacunar stroke patients was 38.0% (interquartile range 30.5–48.3%). Early HT was detected in 11 patients (9.6%), and these patients had significantly lower coated‐platelet levels compared with those without early HT [median 25.1% (interquartile range 20.4–35.5%) vs. 39.2% (31.6–49.5%), P = 0.003]. Conclusions : Lower levels of coated‐platelets are associated with the presence of early HT in patients with non‐lacunar ischemic stroke.