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Molecular control of blood flow and angiogenesis: role of nitric oxide
Author(s) -
SESSA W. C.
Publication year - 2009
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1111/j.1538-7836.2009.03424.x
Subject(s) - nitric oxide , bradykinin , angiogenesis , mediator , endothelium , blood flow , regulator , vascular permeability , hemodynamics , blood vessel , endothelial stem cell , vasodilation , vascular smooth muscle , medicine , microbiology and biotechnology , chemistry , biology , in vitro , biochemistry , smooth muscle , receptor , gene
Summary. In the past decade, the importance of the vascular endothelium as a multifunctional regulator of vascular smooth muscle physiology and pathophysiology has been appreciated . Indeed, the endothelium responds to hemodynamic stimuli (pressure, shear stress and wall strain) and locally manufactured mediators (such as bradykinin, prostaglandins, angiotensin II and nitric oxide) that can influence blood flow, cell trafficking into tissue and angiogenesis. In this chapter, the importance of nitric oxide (NO) as a mediator of blood flow control, vascular permeability and angiogenesis will be discussed.